:root{
  --navy:#083b63;--navy2:#0d4c78;--blue:#2178a7;--teal:#148f98;--teal2:#63c1c6;
  --ink:#17344c;--muted:#667c8f;--line:#dfe9ef;--soft:#f5f9fc;--soft2:#edf6f8;
  --white:#fff;--max:1190px;--radius:20px;--shadow:0 18px 48px rgba(8,59,99,.10);
}
*{box-sizing:border-box}html{scroll-behavior:smooth}body{margin:0;font-family:Inter,ui-sans-serif,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;color:var(--ink);background:#fff;line-height:1.56;-webkit-font-smoothing:antialiased}a{color:inherit;text-decoration:none}img{display:block;max-width:100%}button,input,select,textarea{font:inherit}.container{width:min(var(--max),calc(100% - 44px));margin-inline:auto}.eyebrow{font-size:.74rem;letter-spacing:.18em;text-transform:uppercase;color:var(--blue);font-weight:800}.muted{color:var(--muted)}.small{font-size:.86rem}.badge{display:inline-flex;align-items:center;gap:.42rem;padding:.34rem .62rem;border-radius:999px;background:#e9f6f7;color:#0c7480;font-size:.7rem;font-weight:800;letter-spacing:.05em;text-transform:uppercase}.btn{display:inline-flex;align-items:center;justify-content:center;gap:.5rem;padding:.86rem 1.08rem;border:1px solid var(--navy);border-radius:10px;font-weight:760;font-size:.91rem;transition:.18s ease;cursor:pointer}.btn:hover{transform:translateY(-1px);box-shadow:var(--shadow)}.btn.primary{background:var(--navy);color:#fff}.btn.secondary{background:#fff;color:var(--navy)}.btn.ghost{border-color:var(--line);background:transparent;color:var(--navy)}h1,h2,h3,h4{color:var(--navy);letter-spacing:-.03em;margin-top:0}h1{font-size:clamp(3.25rem,6.3vw,5.7rem);line-height:.92;margin-bottom:20px}h2{font-size:clamp(2.05rem,3.5vw,3.05rem);line-height:1.04;margin-bottom:13px}h3{font-size:1.08rem;margin-bottom:8px}h4{font-size:.98rem;margin-bottom:7px}p{margin-top:0}.lead{font-size:1.08rem;color:#48657c;max-width:780px}.section{padding:80px 0;border-bottom:1px solid var(--line)}.section.soft{background:var(--soft)}.section-head{display:grid;grid-template-columns:270px 1fr;gap:54px;align-items:start;margin-bottom:34px}.card{border:1px solid var(--line);border-radius:var(--radius);background:#fff;box-shadow:0 8px 26px rgba(16,64,95,.035)}.card.pad{padding:25px}.grid-2{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}.grid-3{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.grid-4{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:18px}.link{display:inline-flex;gap:.38rem;align-items:center;color:var(--blue);font-weight:760;font-size:.86rem;margin-top:7px}.link:hover{text-decoration:underline}.rule{height:1px;background:var(--line);margin:30px 0}
/* header */
.site-header{position:sticky;top:0;z-index:50;background:rgba(255,255,255,.95);backdrop-filter:blur(14px);border-bottom:1px solid rgba(223,233,239,.92)}.nav{min-height:78px;display:flex;align-items:center;justify-content:space-between;gap:22px}.brand{display:flex;align-items:center;gap:11px;min-width:200px}.brand-mark{width:45px;height:45px;object-fit:contain}.brand-copy{line-height:1.02}.brand-name{font-size:1.14rem;font-weight:850;color:var(--navy);letter-spacing:-.03em}.brand-name span{font-weight:420}.brand-sub{font-size:.58rem;color:#677d8e;margin-top:4px;white-space:nowrap}.nav-links{display:flex;align-items:center;gap:21px;color:#35516a;font-size:.87rem;font-weight:700}.nav-links a:hover,.nav-links a.active{color:var(--blue)}.nav-tools{display:flex;align-items:center;gap:12px}.lang{font-size:.74rem;color:var(--muted)}.menu{display:none;border:0;background:none;font-size:1.55rem;color:var(--navy);cursor:pointer}.mini-affiliations{display:flex;align-items:center;gap:12px;margin-left:2px;padding-left:14px;border-left:1px solid var(--line)}.mini-affiliations img{height:24px;width:auto;max-width:78px;object-fit:contain}.mini-affiliations .usi-mini{height:29px}
/* hero */
.hero{position:relative;overflow:hidden;background:linear-gradient(100deg,#fff 0%,#f9fbfd 47%,#edf6f8 100%);border-bottom:1px solid var(--line)}.hero:after{content:"";position:absolute;right:-180px;top:-170px;width:640px;height:640px;border-radius:50%;border:1px solid rgba(33,120,167,.12);box-shadow:0 0 0 98px rgba(33,120,167,.034),0 0 0 194px rgba(20,143,152,.02)}.hero-grid{min-height:620px;display:grid;grid-template-columns:1.03fr .97fr;gap:58px;align-items:center;position:relative;z-index:2}.hero-copy p{font-size:1.12rem;color:#48657c;max-width:620px}.hero-actions{display:flex;gap:12px;flex-wrap:wrap;margin:28px 0 22px}.hero-kicker{font-size:.76rem;letter-spacing:.17em;text-transform:uppercase;color:var(--teal);font-weight:800}.data-panel{min-height:430px;border-radius:28px;position:relative;overflow:hidden;background:linear-gradient(145deg,#083b63,#13527d 58%,#1b8b98);box-shadow:0 30px 70px rgba(8,59,99,.18)}.data-panel .grid{position:absolute;inset:0;background-image:linear-gradient(rgba(255,255,255,.07) 1px,transparent 1px),linear-gradient(90deg,rgba(255,255,255,.07) 1px,transparent 1px);background-size:36px 36px;mask-image:linear-gradient(to bottom right,black,transparent 80%)}.brain-outline{position:absolute;left:9%;top:13%;width:57%;height:60%;border:3px solid rgba(255,255,255,.88);border-radius:48% 52% 47% 53% / 53% 44% 56% 47%}.brain-outline:before,.brain-outline:after{content:"";position:absolute;border:2px solid rgba(255,255,255,.52);border-radius:50%}.brain-outline:before{inset:17% 12% 24% 18%;transform:rotate(12deg)}.brain-outline:after{inset:30% 23% 11% 10%;transform:rotate(-18deg)}.node{position:absolute;width:13px;height:13px;border-radius:50%;background:#93e7e8;border:2px solid #fff;box-shadow:0 0 0 5px rgba(147,231,232,.11)}.n1{left:27%;top:24%}.n2{left:45%;top:31%}.n3{left:34%;top:48%}.n4{left:52%;top:57%}.n5{left:26%;top:67%}.n6{left:63%;top:41%}.curve{position:absolute;left:11%;right:8%;bottom:17%;height:95px;border-top:4px solid #9ef1ed;border-radius:50% 50% 0 0;transform:rotate(-7deg)}.panel-copy{position:absolute;right:8%;bottom:10%;text-align:right;color:#fff;max-width:205px}.panel-copy strong{display:block;font-size:1.06rem;letter-spacing:.08em;text-transform:uppercase}.panel-copy span{font-size:.84rem;color:#d9f3f5}.hero-brand-badge{position:absolute;left:7%;bottom:8%;width:112px;padding:10px;background:rgba(255,255,255,.93);border-radius:14px;box-shadow:0 10px 24px rgba(0,0,0,.11)}
/* affiliation band */
.affiliation-band{padding:24px 0;border-bottom:1px solid var(--line);background:#fff}.affiliation-inner{display:flex;align-items:center;justify-content:space-between;gap:26px}.affiliation-copy{font-size:.82rem;color:#667c8f}.affiliation-copy strong{display:block;color:var(--navy);font-size:.92rem;margin-bottom:2px}.affiliation-logos{display:flex;align-items:center;gap:30px}.affiliation-logo{height:44px;max-width:155px;object-fit:contain}.affiliation-logo.usi{height:52px;min-width:112px}.affiliation-fallback{font-weight:900;color:var(--navy);font-size:1.05rem}
/* pillars */
.pillar .icon{width:44px;height:44px;border-radius:13px;background:#e9f6f7;color:var(--teal);display:grid;place-items:center;font-weight:900;margin-bottom:18px}.pillar p{color:var(--muted);font-size:.91rem;margin-bottom:0}.pillar{transition:.18s}.pillar:hover{transform:translateY(-3px);box-shadow:var(--shadow)}.flow{margin-top:28px;padding:26px;border-radius:20px;background:#f6fafc;display:grid;grid-template-columns:repeat(5,1fr);gap:18px}.step{text-align:center;position:relative}.step:not(:last-child):after{content:"→";position:absolute;right:-16px;top:18px;color:#91a6b8;font-size:1.4rem}.step .circle{width:48px;height:48px;margin:0 auto 10px;border:1px solid #bfd0db;border-radius:50%;display:grid;place-items:center;background:#fff;color:var(--navy);font-weight:900}.step strong{display:block;color:var(--navy);font-size:.9rem}.step span{display:block;color:var(--muted);font-size:.78rem}
/* project cards */
.project{overflow:hidden;transition:.18s}.project:hover{transform:translateY(-3px);box-shadow:var(--shadow)}.project-art{height:128px;position:relative;background:radial-gradient(circle at 72% 35%,rgba(255,255,255,.24),transparent 15%),linear-gradient(135deg,#0b456d,#178d99)}.project-art:after{content:"";position:absolute;left:20px;right:20px;bottom:29px;height:2px;background:#a9ecea;transform:rotate(-5deg);box-shadow:80px -23px 0 -.5px rgba(255,255,255,.4)}.project-art.registry{background:linear-gradient(135deg,#0a3b62,#126c89)}.project-art.proms{background:linear-gradient(135deg,#1c638d,#1b9ba5)}.project-art.oncology{background:linear-gradient(135deg,#133d67,#526a91)}.project-art.spine{background:linear-gradient(135deg,#12486b,#438493)}.project-art.analytics{background:linear-gradient(135deg,#083b63,#1a768f)}.project-art.microbiome{background:linear-gradient(135deg,#0b5b63,#31928a)}.project-art.global{background:linear-gradient(135deg,#17496e,#4c7593)}.project-art.geriatric{background:linear-gradient(135deg,#4a5e77,#178d99)}.project-body{padding:23px}.project-body p{font-size:.9rem;color:var(--muted)}.project-number{font-size:.74rem;font-weight:850;color:var(--teal);letter-spacing:.12em;text-transform:uppercase}
/* page hero */
.page-hero{padding:94px 0 68px;background:linear-gradient(100deg,#fff,#f0f8fa);border-bottom:1px solid var(--line);position:relative;overflow:hidden}.page-hero:after{content:"";position:absolute;width:430px;height:430px;border:1px solid rgba(33,120,167,.10);border-radius:50%;right:-160px;top:-170px;box-shadow:0 0 0 70px rgba(33,120,167,.025)}.page-hero .container{position:relative;z-index:2}.page-hero h1{font-size:clamp(3.05rem,5.2vw,4.85rem);max-width:980px}.page-hero p{font-size:1.08rem;max-width:790px;color:#48657c}.page-actions{display:flex;gap:10px;flex-wrap:wrap;margin-top:24px}
/* research */
.topic-list{display:grid;gap:14px}.topic-row{display:grid;grid-template-columns:110px 1fr auto;gap:20px;align-items:center;padding:21px;border:1px solid var(--line);border-radius:17px;background:#fff}.topic-row .num{color:var(--teal);font-weight:850}.topic-row p{margin:4px 0 0;color:var(--muted);font-size:.9rem}.method{padding:24px}.method strong{color:var(--navy);display:block;margin-bottom:8px}.method p{font-size:.9rem;color:var(--muted);margin:0}.question{padding:24px;border-left:3px solid var(--teal)}.question .qnum{font-size:.72rem;color:var(--teal);font-weight:850;letter-spacing:.12em;text-transform:uppercase}.question h3{margin:8px 0}.domain{padding:22px}.domain p{font-size:.9rem;color:var(--muted);margin-bottom:0}
/* project detail */
.detail-grid{display:grid;grid-template-columns:minmax(0,1fr) 310px;gap:50px;align-items:start}.detail-main h2{font-size:2rem;margin-top:44px}.detail-main h2:first-child{margin-top:0}.detail-main p{color:#4d687e}.detail-main ul{color:#4d687e;padding-left:1.25rem}.detail-main li{margin:.5rem 0}.sidebar{position:sticky;top:108px}.sidebar-card{padding:22px}.sidebar-card + .sidebar-card{margin-top:14px}.sidebar-title{font-size:.72rem;text-transform:uppercase;letter-spacing:.14em;color:var(--blue);font-weight:850;margin-bottom:10px}.meta-list{display:grid;gap:12px}.meta-row{border-top:1px solid var(--line);padding-top:10px}.meta-row:first-child{border-top:0;padding-top:0}.meta-row strong{display:block;color:var(--navy);font-size:.82rem}.meta-row span{font-size:.84rem;color:var(--muted)}.registry-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}.registry-item{padding:24px;border-top:3px solid var(--teal)}.registry-item p{font-size:.91rem;color:var(--muted);margin-bottom:0}.objective-list{display:grid;gap:12px;margin-top:18px}.objective{padding:18px 20px;background:var(--soft);border-radius:14px;color:#48657c}.objective strong{color:var(--navy)}
/* publications */
.empty-state{padding:48px;border:1px solid var(--line);border-radius:24px;background:linear-gradient(135deg,#fbfdfe,#eff7f9);text-align:center}.empty-icon{width:64px;height:64px;margin:0 auto 18px;border-radius:50%;background:#e6f5f6;color:var(--teal);display:grid;place-items:center;font-size:1.5rem;font-weight:900}.empty-state h2{font-size:2.2rem}.empty-state p{max-width:670px;margin:0 auto 22px;color:#5b7286}.output-grid{margin-top:25px}
/* team */
.team-group{margin-top:46px}.team-group:first-child{margin-top:0}.team-group-head{display:flex;align-items:end;justify-content:space-between;gap:20px;margin-bottom:18px;padding-bottom:12px;border-bottom:1px solid var(--line)}.team-group-head h2{font-size:1.75rem;margin-bottom:0}.team-grid-leaders{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}.team-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.person-card{padding:24px;display:flex;align-items:center;gap:20px;min-height:154px}.person-photo{width:104px;height:104px;border-radius:50%;position:relative;overflow:hidden;flex:0 0 104px;background:linear-gradient(145deg,#dceaf0,#f8fbfd);border:1px solid #d9e5ec;display:grid;place-items:center;color:#6a8498;font-size:1.35rem;font-weight:850}.person-photo .img-fallback{position:absolute;inset:0;display:grid;place-items:center}.person-photo img{position:absolute;inset:0;width:100%;height:100%;object-fit:cover}.person-photo.zaed img{object-position:50% 27%}.person-photo.milani img{transform:scale(2.18);transform-origin:0 0;object-position:0 0}.person-info h3{margin-bottom:3px;font-size:1rem}.person-role{font-size:.82rem;color:var(--teal);font-weight:800;margin-bottom:5px}.person-detail{font-size:.82rem;color:var(--muted);margin:0}.person-simple{padding:22px}.person-simple h3{margin-bottom:5px}.person-simple p{margin:0;color:var(--muted);font-size:.86rem}
/* about */
.brand-showcase{padding:30px;display:grid;place-items:center;min-height:320px}.brand-showcase img{max-width:470px}.principle{padding:24px}.principle .num{font-weight:900;color:var(--teal);font-size:.74rem;letter-spacing:.12em}.principle p{font-size:.9rem;color:var(--muted);margin-bottom:0}
/* collaborate/contact */
.cta{background:linear-gradient(120deg,#083b63,#0e557d 58%,#127b86);color:#fff}.cta .container{display:grid;grid-template-columns:1.2fr .8fr;gap:60px;align-items:center}.cta h2{color:#fff}.cta p{color:#d8e9f2}.quote{border-left:1px solid rgba(255,255,255,.35);padding-left:28px;font-family:Georgia,serif;font-size:1.45rem;line-height:1.28;font-style:italic;color:#eef9fa}.contact-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:18px}.contact-box{padding:25px}.contact-box p{color:var(--muted)}.email-box{padding:30px;background:linear-gradient(135deg,#083b63,#137688);color:#fff;border:0}.email-box h3{color:#fff}.email-box p{color:#dceef2}.email-link{display:inline-block;font-weight:850;font-size:1.1rem;border-bottom:1px solid rgba(255,255,255,.5)}.privacy-note{padding:16px 18px;border-left:3px solid var(--teal);background:#f2fafb;border-radius:8px;color:#526a7e;font-size:.88rem}
/* footer */
footer{padding:38px 0;background:#fff}.footer-grid{display:grid;grid-template-columns:1fr 1.25fr .9fr;gap:32px;align-items:start;font-size:.82rem;color:#5d7487}.footer-brand{display:flex;align-items:center;gap:10px}.footer-brand img{width:43px}.footer-brand strong{font-size:1.05rem;color:var(--navy)}.footer-grid strong{color:var(--navy)}.footer-logos{display:flex;align-items:center;gap:18px;margin-top:12px}.footer-logos img{height:34px;max-width:100px;object-fit:contain}.footer-logos .usi{height:42px}.footer-links{display:flex;gap:14px;flex-wrap:wrap;margin-top:10px}.footer-links a{color:var(--blue)}
.note{padding:16px 18px;border-left:3px solid var(--teal);background:#f2fafb;border-radius:8px;color:#526a7e;font-size:.9rem}.list-clean{margin:0;padding-left:1.1rem;color:#506b80}.list-clean li{margin:.42rem 0}.external::after{content:" ↗"}
@media(max-width:1080px){.mini-affiliations{display:none}}
@media(max-width:980px){.nav-links{display:none;position:absolute;left:20px;right:20px;top:78px;padding:18px;background:#fff;border:1px solid var(--line);border-radius:16px;box-shadow:var(--shadow);flex-direction:column;align-items:flex-start}.nav-links.open{display:flex}.menu{display:block}.lang{display:none}.hero-grid{grid-template-columns:1fr;padding:70px 0;min-height:auto}.data-panel{min-height:360px}.section-head{grid-template-columns:1fr;gap:18px}.grid-4{grid-template-columns:repeat(2,1fr)}.grid-3{grid-template-columns:repeat(2,1fr)}.cta .container{grid-template-columns:1fr}.footer-grid{grid-template-columns:1fr}.topic-row{grid-template-columns:70px 1fr}.topic-row .link{grid-column:2}.contact-grid{grid-template-columns:1fr}.detail-grid{grid-template-columns:1fr}.sidebar{position:static}.team-grid{grid-template-columns:repeat(2,1fr)}.affiliation-inner{align-items:flex-start;flex-direction:column}.registry-grid{grid-template-columns:1fr}}
@media(max-width:650px){.container{width:min(var(--max),calc(100% - 28px))}.brand-sub{display:none}.brand-mark{width:40px;height:40px}.section{padding:60px 0}.hero-grid{padding:60px 0}.data-panel{min-height:300px}.grid-4,.grid-3,.grid-2,.team-grid,.team-grid-leaders{grid-template-columns:1fr}.flow{grid-template-columns:1fr 1fr}.step:not(:last-child):after{display:none}.quote{font-size:1.2rem}.page-hero{padding:70px 0 52px}.affiliation-logos{gap:18px;flex-wrap:wrap}.affiliation-logo{height:38px}.affiliation-logo.usi{height:44px}.person-card{align-items:flex-start}.person-photo{width:88px;height:88px;flex-basis:88px}.brand-showcase img{max-width:100%}}

.org-logo-shell{position:relative;display:inline-grid;place-items:center;min-width:86px;min-height:32px;color:var(--navy);font-weight:900;letter-spacing:.03em}.org-logo-shell.usishell{min-width:130px}.org-logo-shell .org-fallback{grid-area:1/1;font-size:.85rem;white-space:nowrap}.org-logo-shell img{grid-area:1/1;position:relative;background:#fff;max-width:100%;object-fit:contain}.mini-affiliations .org-logo-shell{min-width:45px;min-height:24px}.mini-affiliations .org-logo-shell.usishell{min-width:68px}.mini-affiliations .org-logo-shell .org-fallback{font-size:.68rem}.footer-logos .org-logo-shell{min-width:70px}.footer-logos .org-logo-shell.usishell{min-width:112px}.affiliation-logos .org-logo-shell{min-width:118px;min-height:48px}.affiliation-logos .org-logo-shell.usishell{min-width:160px}